Haydon's acting debut was in the ensemble romantic comedy-drama Aisha (2010), and she received critical praise for her performance in the comedy-drama Queen.
She was born to an Indian father and an Australian mother. Lisa was born in Chennai, India, and has lived in Australia and the US. She started modeling in Australia at the age of 19 and then moved to India in 2007 at the age of 21.
She won Vogue Beauty Award for Best Breakthrough, Filmfare Award for Best Supporting Actress, IIFA Award for Best Supporting Actress, Screen Award for Best Supporting Actress in 2015 for her movie Queen